중앙대학교 제약산업특성화대학원의 양명석, 서진욱 학생이 10월18일~20일 서울 더케이서울호텔에서 열린

대한약학회 70주년 국제 학술대회에서 포스터 발표를 했습니다.

Title:

Adherence to guideline on use of analgesics in patients with first myocardial infarction event: a stepped-care approach

Authors:

First author: Myungsuk Yang¹

Co-authors: Seung Yeon Song², Jinuk Suh¹, Hyunjun Shim¹, Jihee Yun¹, Eunyoung Kim^1,2

Affiliation :

1 Department of Pharmaceutical Industry Management, Graduate School, Chung-Ang University, Seoul, South Korea

2 Department of Health, Social and Clinical Pharmacy, College of Pharmacy, Chung-Ang University, Seoul, South Korea

Key words:

Stepped-care approach, Analgesic, Cardiovascular event

The study aims were to assess adherence to the american heart association guideline on the use of non-steroidal anti-inflammatory drugs (NSAIDs) with a stepped-care approach and to compare the risk of cardiovascular(CV) events between patients treated with guideline adherence and those without.
Using national health insurance sharing service cohort database, patients with first myocardial infarction (MI) between 2008 and 2011 included and guideline adherence was assessed with 2-year follow up. With propensity score matching (PSM), kaplan-meier curve and cox regression analyses were conducted.

Between 2008 and 2011, Only 20% of first-time MI patients were treated analgesics with adherence to the stepped-care approach. After PSM using covariates, 216 patients were included in each group. All patients were followed until either a CV event (death, MI, stroke, transient ischemic attack, embolism) whichever occurred first or up to 2 years.

Using kaplan-meier methods, showed statistical significance between two groups in time-to event. Using multivariate cox regression analysis, use of acetaminophen and/or narcotics, non-selective NSAIDs and selective NSAIDs increase CV event risk from least to most both two groups.

We found that the guideline-concordant group represents better prognosis compared to the discordant group. Our results suggest that increased and multidisciplinary efforts are required to increase adherence to the guideline recommendations to help prevent CV events in MI patients when using NSAIDs.

Title: Prescription patterns and appropriateness of mupirocin in ambulatory care using the Korean National Health Insurance Claims database

Authors: Kyeong Hye Jeong, Eunyoung Kim

First author: Jinuk Suh

Co-authors: Kyeong Hye Jeong, Eunyoung Kim

Key words: Mupirocin, Ambulatory setting, Prescription patterns, Appropriateness of prescription

Background: Mupirocin has been widely used as topical antimicrobial agent for many years and can be used for patients with methicillin-resistant Staphylococcus aureus. However, recent studies show that mupirocin resistance have been increasing. The objective of this study was to investigate prescription patterns of mupirocin, which is known to be highly correlated with antimicrobial resistance, to evaluate appropriateness of prescriptions in the ambulatory setting and to compare frequency of mupirocin usage in South Korea with that in United States.

Methods: The 2012 Health Insurance and Review and Assessment service-National Patient Sample dataset of South Korea was used to analyze mupirocin prescription patterns (the number of prescription and a prescription period) and to evaluate appropriateness of prescription (a prescription rate over 10 days, a repeat prescription rate within 30 days and a prescription rate within labeled indications). The National Ambulatory Medical Care Survey dataset was used to quantify mupirocin prescription in United States for comparison.

Results: In South Korea, the mean duration of prescribed use was 1.12 days, the prescriptions rate for use over 10 days was 3%, the repeat prescription rate within 30 days was 8.87% and the prescription proportion within labeled indications was 33.84%. The most frequent diagnostic code was nonbacterial infection. The prescription rate (per 1000 population) of mupirocin in South Korea was calculated to be 46.07, whereas in United States was calculated to be 13.10.

Conclusion: Mupirocin is used frequently and inappropriately, so further studies are required to investigate the rationale behind such prescribing mupirocin patterns.